Anne Rockwell was born in Memphis, Tennessee on February 8, 1934. She moved to New York City at the age of 18 and found a job doing typing work for a textbook publisher. She studied at Pratt Graphic Arts Center and at the Sculpture Center.
She became an author and illustrator. Her first children's book, Paul and Arthur Search for the Egg, was published in 1964. Her other books included Boats, Fire Engines, Things That Go, Our Earth, and Only Passing Through: The Story of Sojourner Truth. She collaborated on several books with her husband Harlow Rockwell including Sally's Caterpillar and The Toolbox. After her husband's death, she collaborated with her daughter Lizzy Rockwell. Their books included Career Day and Zoo Day. She died of natural causes on April 10, 2018 at the age of 85.